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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026844,
umls-concept:C0086597,
umls-concept:C0389995,
umls-concept:C0600210,
umls-concept:C0851827,
umls-concept:C1335631,
umls-concept:C1412517,
umls-concept:C1423613,
umls-concept:C1701901,
umls-concept:C1720675
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pubmed:issue |
4
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pubmed:dateCreated |
2008-8-20
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pubmed:abstractText |
The lysophospholipid mediator sphingosine-1-phosphate (S1P) activates G protein-coupled receptors (GPCRs) to induce potent inhibition of platelet-derived growth factor (PDGF)-induced Rac activation and, thereby, chemotaxis in rat vascular smooth muscle cells (VSMCs). We explored the heterotrimeric G protein and the downstream mechanism that mediated S1P inhibition of Rac and cell migration in VSMCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp...,
http://linkedlifedata.com/resource/pubmed/chemical/ADP Ribose Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Botulinum Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/JTE 013,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-sis,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysosphingolipid,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/exoenzyme C3, Clostridium botulinum,
http://linkedlifedata.com/resource/pubmed/chemical/fasudil,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
689-97
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18480127-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:18480127-ADP Ribose Transferases,
pubmed-meshheading:18480127-Animals,
pubmed-meshheading:18480127-Botulinum Toxins,
pubmed-meshheading:18480127-Calcium,
pubmed-meshheading:18480127-Cell Movement,
pubmed-meshheading:18480127-Cells, Cultured,
pubmed-meshheading:18480127-Dose-Response Relationship, Drug,
pubmed-meshheading:18480127-GTP-Binding Protein alpha Subunits, G12-G13,
pubmed-meshheading:18480127-GTP-Binding Protein alpha Subunits, Gq-G11,
pubmed-meshheading:18480127-Lysophospholipids,
pubmed-meshheading:18480127-Male,
pubmed-meshheading:18480127-Muscle, Smooth, Vascular,
pubmed-meshheading:18480127-Protein Kinase C,
pubmed-meshheading:18480127-Protein Kinase Inhibitors,
pubmed-meshheading:18480127-Proto-Oncogene Proteins c-sis,
pubmed-meshheading:18480127-Pyrazoles,
pubmed-meshheading:18480127-Pyridines,
pubmed-meshheading:18480127-Rats,
pubmed-meshheading:18480127-Rats, Wistar,
pubmed-meshheading:18480127-Receptor, Angiotensin, Type 1,
pubmed-meshheading:18480127-Receptors, Lysosphingolipid,
pubmed-meshheading:18480127-Recombinant Fusion Proteins,
pubmed-meshheading:18480127-Signal Transduction,
pubmed-meshheading:18480127-Sphingosine,
pubmed-meshheading:18480127-Transfection,
pubmed-meshheading:18480127-rac GTP-Binding Proteins,
pubmed-meshheading:18480127-rho GTP-Binding Proteins,
pubmed-meshheading:18480127-rho-Associated Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.
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pubmed:affiliation |
Department of Physiology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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