|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0017262,
umls-concept:C0027651,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0332391,
umls-concept:C0598086,
umls-concept:C0598388,
umls-concept:C0663937,
umls-concept:C0694894,
umls-concept:C0699885,
umls-concept:C1274040,
umls-concept:C1415887,
umls-concept:C1419040,
umls-concept:C1420433,
umls-concept:C1421834,
umls-concept:C1424666,
umls-concept:C2911684
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-5-15
|
|
pubmed:abstractText |
TSC1/hamartin is a tumor suppressor gene involved in the development of various malignancies, including bladder cancer. In vitro studies showed that hamartin controls cell proliferation partly by up-regulating p27 and 14-3-3sigma. This study was designed to explore the value of these biomarkers in predicting outcome in pTa/pT1 tumors and validate the regulation of p27 and 14-3-3sigma by hamartin in vivo using human bladder cancer tissue. A tissue microarray of 134 pTa and pT1 tumors was constructed, and sections were stained with hamartin, 14-3-3sigma, and p27 antibodies. In multiple Cox regression analysis, pTa/pT1 tumors with reduced or low expression of hamartin tended to have higher risk of progression (P = .030). High-grade tumors tended to be at higher risk of progression in comparison with low-grade tumors (P < .001). The combination of expression of these 3 biomarkers did not add predictive value regarding disease outcomes. Low hamartin expression and high tumor grade are independent factors in predicting faster pTa/pT1 tumor progression. In a subset of pTa/pT1 tumors, hamartin has a role in bladder carcinogenesis by positively regulating 14-3-3sigma and p27.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/14-3-3 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Exonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SFN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tuberous sclerosis complex 1 protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0002-9173
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
129
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
918-23
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:18480009-14-3-3 Proteins,
pubmed-meshheading:18480009-Adult,
pubmed-meshheading:18480009-Aged,
pubmed-meshheading:18480009-Aged, 80 and over,
pubmed-meshheading:18480009-Carcinoma, Transitional Cell,
pubmed-meshheading:18480009-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:18480009-DNA, Neoplasm,
pubmed-meshheading:18480009-Exonucleases,
pubmed-meshheading:18480009-Female,
pubmed-meshheading:18480009-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18480009-Humans,
pubmed-meshheading:18480009-Male,
pubmed-meshheading:18480009-Middle Aged,
pubmed-meshheading:18480009-Neoplasm Proteins,
pubmed-meshheading:18480009-Neoplasm Recurrence, Local,
pubmed-meshheading:18480009-Retrospective Studies,
pubmed-meshheading:18480009-Tissue Array Analysis,
pubmed-meshheading:18480009-Tumor Markers, Biological,
pubmed-meshheading:18480009-Tumor Suppressor Proteins,
pubmed-meshheading:18480009-Urinary Bladder Neoplasms,
pubmed-meshheading:18480009-Urothelium
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Association of TSC1/hamartin, 14-3-3sigma, and p27 expression with tumor outcomes in patients with pTa/pT1 urothelial bladder carcinoma.
|
|
pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
|
|
pubmed:publicationType |
Journal Article
|
