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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-6-5
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pubmed:abstractText |
Ring-opened analogues of dihydrobenzopyran potassium channel openers (PCOs) were prepared and evaluated as putative PCOs on rat aorta rings (myorelaxant effect) and rat pancreatic beta-cells (inhibition of insulin secretion). These derivatives are characterized by the presence of a sulfonylurea, a urea or an amide function. Some compounds bearing an arylurea moiety provoked vasorelaxant effects and a marked inhibition of insulin release. Derivatives bearing a sulfonylurea or an amide function were, however, poorly active on both tissues. Structure-activity relationships and apparent tissue selectivity are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6124-30
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18479927-Animals,
pubmed-meshheading:18479927-Aorta,
pubmed-meshheading:18479927-Benzopyrans,
pubmed-meshheading:18479927-Chromans,
pubmed-meshheading:18479927-Cromakalim,
pubmed-meshheading:18479927-Insulin,
pubmed-meshheading:18479927-Insulin Antagonists,
pubmed-meshheading:18479927-Insulin-Secreting Cells,
pubmed-meshheading:18479927-Muscle Relaxation,
pubmed-meshheading:18479927-Potassium Channels,
pubmed-meshheading:18479927-Rats,
pubmed-meshheading:18479927-Rats, Wistar
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
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pubmed:affiliation |
Laboratoire de chimie pharmaceutique, de pharmacologie et d'ecotoxicologie, Faculté des sciences, Université de Jijel, B.P. 98 Ouled Aissa, 18000 Jijel, Algeria.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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