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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-6-6
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pubmed:abstractText |
Surgical brain injury (SBI) is unavoidable during many neurosurgical procedures. This inevitable brain injury can result in post-operative complications including brain edema, blood-brain barrier disruption (BBB) and cell death in susceptible areas. Rosiglitazone (RSG), a PPAR-gamma agonist, has been shown to reduce inflammation and provide neuroprotection in experimental models of ischemia and intracerebral hemorrhage. This study was designed to evaluate the neuroprotective effects of RSG in a rodent model of SBI.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-10078396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-11462765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-1351252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-14530924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-16034372,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-17404835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-17432722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-17457822,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18479673-9473615
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
1215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-24
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pubmed:dateRevised |
2011-6-1
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pubmed:meshHeading |
pubmed-meshheading:18479673-Analysis of Variance,
pubmed-meshheading:18479673-Animals,
pubmed-meshheading:18479673-Blood-Brain Barrier,
pubmed-meshheading:18479673-Brain Edema,
pubmed-meshheading:18479673-Brain Injuries,
pubmed-meshheading:18479673-Disease Models, Animal,
pubmed-meshheading:18479673-Drug Administration Schedule,
pubmed-meshheading:18479673-Inflammation,
pubmed-meshheading:18479673-Intraoperative Complications,
pubmed-meshheading:18479673-Male,
pubmed-meshheading:18479673-Neuroprotective Agents,
pubmed-meshheading:18479673-Neurosurgical Procedures,
pubmed-meshheading:18479673-PPAR gamma,
pubmed-meshheading:18479673-Peroxidase,
pubmed-meshheading:18479673-Postoperative Complications,
pubmed-meshheading:18479673-Random Allocation,
pubmed-meshheading:18479673-Rats,
pubmed-meshheading:18479673-Rats, Sprague-Dawley,
pubmed-meshheading:18479673-Thiazolidinediones,
pubmed-meshheading:18479673-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents.
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pubmed:affiliation |
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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