Source:http://linkedlifedata.com/resource/pubmed/id/18479471
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2008-6-12
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| pubmed:abstractText |
The study set out to investigate the role of corticotrophin-releasing factor (CRF) and orexin-A in chronic migraine (CM) and medication-overuse headache (MOH). Twenty-seven patients affected by CM and 30 with MOH were enrolled. Control CSF specimens were obtained from 20 age-matched subjects who underwent lumbar puncture for diagnostic purposes, and in all of them CSF and blood tests excluded central nervous system or systemic diseases. Orexin-A and CRF were determined by radioimmunoassay methods. Significantly higher levels of orexin-A and CRF were found in the CSF of MOH and to a lesser extent in patients with CM compared with control subjects (orexin-A: P < 0.001 and P < 0.02; CRF: P < 0.002 and P < 0.0003). A significant positive correlation was also found between CSF orexin-A values and those of CRF (R = 0.71; P < 0.0008), monthly drug intake group (R = 0.39; P < 0.03) and scores of a self-completion 10-item instrument to measure dependence upon a variety of substances, the Leeds Dependence Questionnaire (LDQ) in the MOH group (R = 0.68; P < 0.0003). The significantly higher orexin-A levels found in CM and MOH can be interpreted as a compensatory response to chronic head pain or, alternatively, as an expression of hypothalamic response to stress due to chronic pain. A potential role for orexin-A in driving drug seeking in MOH patients through activation of stress pathways in the brain can also be hypothesized.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1468-2982
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
28
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
714-22
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:18479471-Adult,
pubmed-meshheading:18479471-Analgesics,
pubmed-meshheading:18479471-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:18479471-Corticotropin-Releasing Hormone,
pubmed-meshheading:18479471-Drug Therapy, Combination,
pubmed-meshheading:18479471-Female,
pubmed-meshheading:18479471-Headache Disorders,
pubmed-meshheading:18479471-Headache Disorders, Secondary,
pubmed-meshheading:18479471-Humans,
pubmed-meshheading:18479471-Hypothalamus,
pubmed-meshheading:18479471-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18479471-Magnetic Resonance Imaging,
pubmed-meshheading:18479471-Male,
pubmed-meshheading:18479471-Middle Aged,
pubmed-meshheading:18479471-Migraine Disorders,
pubmed-meshheading:18479471-Neuropeptides,
pubmed-meshheading:18479471-Radioimmunoassay,
pubmed-meshheading:18479471-Reference Values,
pubmed-meshheading:18479471-Spinal Puncture,
pubmed-meshheading:18479471-Stress, Physiological
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| pubmed:year |
2008
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| pubmed:articleTitle |
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid.
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| pubmed:affiliation |
Neurologic Clinic, University of Perugia, Perugia, Italy. neuro.pg@tiscalinet.it
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| pubmed:publicationType |
Journal Article
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