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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026809,
umls-concept:C0032214,
umls-concept:C0035820,
umls-concept:C0040223,
umls-concept:C0439228,
umls-concept:C0600138,
umls-concept:C0909868,
umls-concept:C1272745,
umls-concept:C1326961
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-7
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pubmed:abstractText |
The physiological effects of glucocorticoids in a given tissue are driven by the local level of the active glucocorticoid, which is determined by two sources: the plasma cortisol in human (or corticosterone in rodents) and the cortisol produced locally through 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity. Because of the circadian variation of plasma glucocorticoids, the pharmacological efficacy of 11beta-HSD1 inhibition may depend on the time of the day for inhibitor administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1463-1326
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-17
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pubmed:dateRevised |
2009-11-3
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pubmed:meshHeading |
pubmed-meshheading:18479468-11-beta-Hydroxysteroid Dehydrogenase Type 1,
pubmed-meshheading:18479468-Adipose Tissue,
pubmed-meshheading:18479468-Animals,
pubmed-meshheading:18479468-Blood Glucose,
pubmed-meshheading:18479468-Corticosterone,
pubmed-meshheading:18479468-DNA Primers,
pubmed-meshheading:18479468-Diet,
pubmed-meshheading:18479468-Drug Chronotherapy,
pubmed-meshheading:18479468-Enzyme Inhibitors,
pubmed-meshheading:18479468-Homeostasis,
pubmed-meshheading:18479468-Lipid Metabolism,
pubmed-meshheading:18479468-Liver,
pubmed-meshheading:18479468-Male,
pubmed-meshheading:18479468-Mice,
pubmed-meshheading:18479468-Mice, Inbred C57BL,
pubmed-meshheading:18479468-Random Allocation,
pubmed-meshheading:18479468-Thiazoles,
pubmed-meshheading:18479468-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice.
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pubmed:affiliation |
Department of Metabolic Disorders, Amgen Inc., Thousand Oaks, CA 91320, USA. mveniant@amgen.com
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pubmed:publicationType |
Journal Article
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