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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1991-4-10
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pubmed:abstractText |
Monocyte-endothelial interactions are of fundamental importance in determining the movement of monocytes from the blood stream into the vessel wall. This study reports that two endothelium-derived factors, nitric oxide and prostacyclin, alter in vitro monocyte behavior. Nitric oxide (greater than 10(-5) M) inhibited monocyte adhesion to porcine aortic endothelial cell monolayers, whereas prostacyclin (10(-9) to 10(-5) M) had no effect. Both nitric oxide and prostacyclin inhibited monocyte chemotaxis stimulated by N-formyl-methionyl-leucyl-phenylalanine and induced dose-dependent increases in intracellular cyclic guanosine monophosphate and cyclic adenosine monophosphate concentrations, respectively. The cell surface expression of the CD11b/CD18 adhesion receptor, a glycoprotein complex known to mediate monocyte intracellular adhesion, was not altered by either nitric oxide or by prostacyclin. Thus, endothelium-derived nitric oxide and prostacyclin may have a physiological role in modulating monocyte-vascular wall interactions. Alterations in this system may contribute to the increased monocyte emigration from the blood stream into the vessel wall observed in atherogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Epoprostenol,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase
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pubmed:status |
MEDLINE
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pubmed:issn |
1049-8834
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
254-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1847823-Animals,
pubmed-meshheading:1847823-Antigens, CD,
pubmed-meshheading:1847823-Cell Adhesion,
pubmed-meshheading:1847823-Cells, Cultured,
pubmed-meshheading:1847823-Chemotaxis, Leukocyte,
pubmed-meshheading:1847823-Cyclic AMP,
pubmed-meshheading:1847823-Cyclic GMP,
pubmed-meshheading:1847823-Endothelium, Vascular,
pubmed-meshheading:1847823-Epoprostenol,
pubmed-meshheading:1847823-Humans,
pubmed-meshheading:1847823-Monocytes,
pubmed-meshheading:1847823-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:1847823-Nitric Oxide,
pubmed-meshheading:1847823-Superoxide Dismutase,
pubmed-meshheading:1847823-Swine
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pubmed:articleTitle |
Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.
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pubmed:affiliation |
Department of Medicine, King's College School of Medicine and Dentistry, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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