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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-5-14
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pubmed:abstractText |
Recombinant human growth hormone (rhGH) is a salutary modulator of posttraumatic metabolic responses. However, rhGH administration is associated with deleterious side effects, such as hyperglycemia, increased free fatty acids, and triglycerides, which limit its use. Administration of beta-blocker attenuates cardiac work and resting energy expenditure after severe thermal injury and improves fat metabolism and insulin sensitivity. Therefore, the combination of rhGH plus propranolol appears ideal. The aim of the present study was to determine whether rhGH plus propranolol improves hypermetabolism and the inflammatory and acute phase response after severe burn without causing adverse side effects.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1529-7535
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-16
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pubmed:meshHeading |
pubmed-meshheading:18477935-Adolescent,
pubmed-meshheading:18477935-Adrenergic beta-Antagonists,
pubmed-meshheading:18477935-Burns,
pubmed-meshheading:18477935-Child,
pubmed-meshheading:18477935-Cytokines,
pubmed-meshheading:18477935-Drug Therapy, Combination,
pubmed-meshheading:18477935-Energy Metabolism,
pubmed-meshheading:18477935-Female,
pubmed-meshheading:18477935-Human Growth Hormone,
pubmed-meshheading:18477935-Humans,
pubmed-meshheading:18477935-Inflammation,
pubmed-meshheading:18477935-Male,
pubmed-meshheading:18477935-Propranolol,
pubmed-meshheading:18477935-Prospective Studies,
pubmed-meshheading:18477935-Recombinant Proteins,
pubmed-meshheading:18477935-Texas,
pubmed-meshheading:18477935-Trauma Severity Indices
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pubmed:year |
2008
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pubmed:articleTitle |
Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children.
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pubmed:affiliation |
Shriners Hospitals for Children and the Department of Surgery, University Texas Medical Branch, Galveston, TX, USA. majeschk@utmb.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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