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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-4-2
|
| pubmed:abstractText |
Although hepatocellular carcinoma is a relatively uncommon tumor in the United States, it is quite common in sub-Saharan Africa and the Far East, where most cases are associated with infection with the hepatitis B virus. We have studied 99 American patients with hepatocellular carcinoma for evidence of hepatitis B or hepatitis C viral infection and compared these findings to those in a group of matched controls with other cancers. The two groups differed in proportion, with hepatitis B surface antigen in serum being significantly higher in patients with hepatocellular carcinoma (7% vs. 0%, p = 0.009). Antibody to hepatitis C virus was also found more frequently in patients with hepatocellular carcinoma (13% vs. 2%, p = 0.002). The relative risk for hepatocellular carcinoma in hepatitis B surface antigen-positive patients was calculated to be 17.3 and for antibody to hepatitis C virus to be 7.3. The attributable fraction of cases related to the hepatitis B surface antigen carrier state was 6.7% and for patients infected with the hepatitis C virus was 11.4%. Approximately three quarters of cases of hepatocellular carcinoma did not have evidence of either hepatitis C or hepatitis B virus infection. These findings provide strong evidence that hepatitis C virus infection is associated with the development of hepatocellular carcinoma, and in the United States may even play a more important role than the hepatitis B virus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0002-9270
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
335-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1847790-Adolescent,
pubmed-meshheading:1847790-Adult,
pubmed-meshheading:1847790-Aged,
pubmed-meshheading:1847790-Aged, 80 and over,
pubmed-meshheading:1847790-Carcinoma, Hepatocellular,
pubmed-meshheading:1847790-Child,
pubmed-meshheading:1847790-Female,
pubmed-meshheading:1847790-Hepatitis B,
pubmed-meshheading:1847790-Hepatitis B Surface Antigens,
pubmed-meshheading:1847790-Hepatitis C,
pubmed-meshheading:1847790-Humans,
pubmed-meshheading:1847790-Liver Neoplasms,
pubmed-meshheading:1847790-Male,
pubmed-meshheading:1847790-Middle Aged,
pubmed-meshheading:1847790-Radioimmunoassay,
pubmed-meshheading:1847790-United States
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
The role of chronic viral hepatitis in hepatocellular carcinoma in the United States.
|
| pubmed:affiliation |
Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
|
| pubmed:publicationType |
Journal Article
|