Linked Life Data

18477704

Source:http://linkedlifedata.com/resource/pubmed/id/18477704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-7-10
pubmed:abstractText
Glucose-sensitive neurons in the lateral hypothalamic area produce orexin-A (OxA) as well as orexin-B (OxB) and send their axons to the spinal dorsal horn, which predominantly expresses orexin receptor-1 (OX-1), showing a higher sensitivity to OxA. The purpose of the present study was to assess the effects of OxA on the induction of a novel form of activity-dependent reflex potentiation, spinal reflex potentiation (SRP), in the pelvic-urethral reflex activity. External urethra sphincter electromyogram in response to pelvic afferent nerve test stimulation (TS; 1/30 Hz) or repetitive stimulation (RS; 1 Hz) was recorded in anesthetized rats. TS evoked a baseline reflex activity, whereas RS produced SRP, which was abolished by intrathecal OxA (30 nM, 10 mul). Intrathecal SB-408124 (10 muM, 10 mul), an OX-1 antagonist, reversed the abolition on SRP caused by OxA. Although there is, so far, no NR2A- and NR2B-specific agonist available, N-methyl-d-aspartate (NMDA) reversed the abolition on the RS-induced SRP caused by the co-administration of OxA and Co-101244 (30 nM, 10 mul; an NMDA NR2B subunit antagonist), but it did not reverse the abolition by the co-administration of OxA and PPPA (300 nM, 10 mul; an NMDA NR2A subunit antagonist). In conclusion, the activation of descending orexinergic fibers may inhibit the repetitive afferent input-induced central sensitization of pelvic-urethral reflex activity and urethra hyperactivity, indicating that spinal orexinergic neural transmission may be a novel target for the treatment of patients with neuropathetic or postinflammatory pain of pelvic origin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0193-1849
pubmed:author
pubmed:issnType
Print
pubmed:volume
295
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E117-29
pubmed:meshHeading
pubmed-meshheading:18477704-Action Potentials, pubmed-meshheading:18477704-Animals, pubmed-meshheading:18477704-Electromyography, pubmed-meshheading:18477704-Excitatory Amino Acid Antagonists, pubmed-meshheading:18477704-Female, pubmed-meshheading:18477704-Immunohistochemistry, pubmed-meshheading:18477704-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:18477704-N-Methylaspartate, pubmed-meshheading:18477704-Neurons, Afferent, pubmed-meshheading:18477704-Neuropeptides, pubmed-meshheading:18477704-Piperazines, pubmed-meshheading:18477704-Piperidines, pubmed-meshheading:18477704-Rats, pubmed-meshheading:18477704-Rats, Wistar, pubmed-meshheading:18477704-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:18477704-Reflex, pubmed-meshheading:18477704-Spinal Cord, pubmed-meshheading:18477704-Synaptic Transmission, pubmed-meshheading:18477704-Urethra
pubmed:year
2008
pubmed:articleTitle
Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit.
pubmed:affiliation
Department of Physiology, College of Medicine, Chung-Shan Medical University Hospital, 110, Chang-Kuo North Rd., Section 1, Taichung, Taiwan .
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't