Linked Life Data

18477510

Source:http://linkedlifedata.com/resource/pubmed/id/18477510

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-6-5
pubmed:abstractText
The following study describes the synthesis of new benzanilide derivatives and their pharmacological investigation on smooth muscle preparations of guinea pigs. All compounds were synthesized in good yields and showed a spasmolytic activity without significant effect on vascular smooth muscles and heart muscle preparations. Moreover, further pharmacological investigations as well as in silico studies were performed to elucidate the mechanism of action. Compound 3 showed the most potent spasmolytic activity with an IC(50) of 3.25microM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1464-3391
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5974-81
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR.
pubmed:affiliation
Department of Pharmaceutical Chemistry, University of Vienna, A-1090 Vienna, Althanstrasse 14, Austria.
pubmed:publicationType
Journal Article