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| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C0175668 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:1847693 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1847693 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1847693 | pubmed:dateCreated | 1991-4-4 | lld:pubmed |
| pubmed-article:1847693 | pubmed:abstractText | The role of epidermal Langerhans' cells in infection with herpes simplex virus (HSV) was investigated using a culture system that supports antigen-specific primary and secondary T-cell proliferative responses. Epidermal cell suspensions were capable of restimulating the response of in vivo primed T cells to UV-inactivated HSV. This capability was also present in cell suspensions enriched for Langerhans' cells, but was abrogated by the depletion of I-A-bearing cells. The magnitude, kinetics and phenotype of the responding cells were similar to those elicited when HSV was presented to primed T cells by antigen-presenting cells from the spleen. In marked contrast, whereas splenic antigen-presenting cells induced strong antigen-specific proliferation of unprimed T cells (primarily of the helper phenotype), Langerhans' cells failed to invoke any detectable reaction of such cells. | lld:pubmed |
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| pubmed-article:1847693 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1847693 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1847693 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1847693 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1847693 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1847693 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1847693 | pubmed:author | pubmed-author:WilliamsN ANA | lld:pubmed |
| pubmed-article:1847693 | pubmed:author | pubmed-author:HillT JTJ | lld:pubmed |
| pubmed-article:1847693 | pubmed:author | pubmed-author:HooperD CDC | lld:pubmed |
| pubmed-article:1847693 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1847693 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:1847693 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1847693 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1847693 | pubmed:pagination | 34-9 | lld:pubmed |
| pubmed-article:1847693 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1847693 | pubmed:meshHeading | pubmed-meshheading:1847693-... | lld:pubmed |
| pubmed-article:1847693 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1847693 | pubmed:articleTitle | Murine epidermal antigen-presenting cells in primary and secondary T-cell proliferative responses to herpes simplex virus in vitro. | lld:pubmed |
| pubmed-article:1847693 | pubmed:affiliation | Department of Microbiology, The Medical School, University of Bristol, U.K. | lld:pubmed |
| pubmed-article:1847693 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1847693 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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