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rdf:type |
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lifeskim:mentions |
umls-concept:C0003315,
umls-concept:C0175668,
umls-concept:C0205225,
umls-concept:C0206558,
umls-concept:C0221920,
umls-concept:C0334094,
umls-concept:C0591833,
umls-concept:C0871261,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1991-4-4
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pubmed:abstractText |
The role of epidermal Langerhans' cells in infection with herpes simplex virus (HSV) was investigated using a culture system that supports antigen-specific primary and secondary T-cell proliferative responses. Epidermal cell suspensions were capable of restimulating the response of in vivo primed T cells to UV-inactivated HSV. This capability was also present in cell suspensions enriched for Langerhans' cells, but was abrogated by the depletion of I-A-bearing cells. The magnitude, kinetics and phenotype of the responding cells were similar to those elicited when HSV was presented to primed T cells by antigen-presenting cells from the spleen. In marked contrast, whereas splenic antigen-presenting cells induced strong antigen-specific proliferation of unprimed T cells (primarily of the helper phenotype), Langerhans' cells failed to invoke any detectable reaction of such cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-1272372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-170376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-2148541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-2784479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-2969460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-2974420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-3015083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-3093102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-3487618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-3875419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-4108425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-4138800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-4328483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-4347057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-4538841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-6162307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-6168700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-6211498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-621393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-6300278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1847693-65155
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1847693-Animals,
pubmed-meshheading:1847693-Antigens, Viral,
pubmed-meshheading:1847693-Epidermis,
pubmed-meshheading:1847693-Female,
pubmed-meshheading:1847693-Immunologic Memory,
pubmed-meshheading:1847693-Langerhans Cells,
pubmed-meshheading:1847693-Lymphocyte Activation,
pubmed-meshheading:1847693-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:1847693-Mice,
pubmed-meshheading:1847693-Mice, Inbred CBA,
pubmed-meshheading:1847693-Simplexvirus,
pubmed-meshheading:1847693-Spleen,
pubmed-meshheading:1847693-T-Lymphocytes
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pubmed:year |
1991
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pubmed:articleTitle |
Murine epidermal antigen-presenting cells in primary and secondary T-cell proliferative responses to herpes simplex virus in vitro.
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pubmed:affiliation |
Department of Microbiology, The Medical School, University of Bristol, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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