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pubmed:abstractText |
Endogenous angiotensin (Ang)-(1-7) enhances, while Ang II attenuates, baroreceptor sensitivity (BRS) for reflex control of heart rate (HR) in Sprague-Dawley (SD) rats. In (mRen2)27 renin transgenic rats [(mRen2)], there is overexpression of the mouse Ren2 gene in brain, leading to elevated Ang II and reduced Ang-(1-7) in brain medullary, and associated with hypertension and impaired BRS.
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pubmed:affiliation |
Hypertension & Vascular Research Center, Division of Surgical Sciences, Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA. ddiz@wfubmc.edu
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