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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-5-13
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pubmed:abstractText |
Pathological 43-kDa transactivating responsive sequence DNA-binding protein (TDP-43) has been identified recently as the major disease protein in amyotrophic lateral sclerosis (ALS), and in frontotemporal lobar degeneration with ubiquitinated inclusions, with or without motor neuron disease, but the distribution of TDP-43 pathology in ALS may be more widespread than previously described.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1538-3687
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
636-41
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pubmed:meshHeading |
pubmed-meshheading:18474740-Aged,
pubmed-meshheading:18474740-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:18474740-Biological Markers,
pubmed-meshheading:18474740-Brain,
pubmed-meshheading:18474740-Brain Mapping,
pubmed-meshheading:18474740-Cohort Studies,
pubmed-meshheading:18474740-DNA-Binding Proteins,
pubmed-meshheading:18474740-Dementia,
pubmed-meshheading:18474740-Diagnosis, Differential,
pubmed-meshheading:18474740-Disease Progression,
pubmed-meshheading:18474740-Female,
pubmed-meshheading:18474740-Humans,
pubmed-meshheading:18474740-Immunohistochemistry,
pubmed-meshheading:18474740-Inclusion Bodies,
pubmed-meshheading:18474740-Longitudinal Studies,
pubmed-meshheading:18474740-Male,
pubmed-meshheading:18474740-Middle Aged,
pubmed-meshheading:18474740-Motor Neuron Disease,
pubmed-meshheading:18474740-Motor Neurons,
pubmed-meshheading:18474740-Neuroglia
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pubmed:year |
2008
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pubmed:articleTitle |
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
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pubmed:affiliation |
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer's Disease Core Center, Institute on Aging, Philadelphia, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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