Linked Life Data

18474553

Source:http://linkedlifedata.com/resource/pubmed/id/18474553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 6
pubmed:dateCreated
2008-5-13
pubmed:abstractText
Human immunodeficiency virus (HIV)-positive women have high rates of cervical squamous intraepithelial lesions (SIL) and concurrent human papillomavirus (HPV) infections with a variety of genotypes whose oncogenic risk is poorly documented. The prevalence and persistence of HPV genotypes and HPV16 variants were analysed in 112 HIV-positive and 115 HIV-negative Italian women. HIV-positive women were more likely than HIV-negative women to be infected by HPV at the initial examination (39.3 vs 13.9 %, P<0.001) and to have a higher period prevalence of HPV infection over a 3-year follow-up (43.8 % vs 17.4 %, P<0.001), regardless of CD4+ cell counts and anti-retroviral therapy. 'High-risk' and 'probable high-risk' HPVs (types 16, 18, 31, 33, 35, 45, 52, 58 and 66), among the 20 different viral genotypes identified, were predominant in HIV-positive (33.9 %) compared with HIV-negative (13.9 %) women. Among HIV-infected women, with normal cytology as well as with SIL of any grade, the most common genotypes were HPV16 followed by HPV81, -58, -72, -33 and -62. HPV16 isolates from 18 HIV-positive and eight HIV-negative women were classified into variant lineages based on sequencing analysis of E6 and E7 genes and the long control region. Whilst the HPV16 G350 European variant was prevalent in both HIV-positive (10.7 %) and -negative women (3.5 %), HPV16 African 2 variant was only detected in HIV-positive women (3.6 %), suggesting different sexual mixing behaviours. The increased prevalence of uncommon viral genotypes and HPV16 variants in HIV-positive Italian women underscores the need to target a wide range of HPV types in cervical screening of high-risk women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1380-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18474553-AIDS-Related Opportunistic Infections, pubmed-meshheading:18474553-Adult, pubmed-meshheading:18474553-Anti-Retroviral Agents, pubmed-meshheading:18474553-CD4 Lymphocyte Count, pubmed-meshheading:18474553-Cervical Intraepithelial Neoplasia, pubmed-meshheading:18474553-Cervix Uteri, pubmed-meshheading:18474553-Female, pubmed-meshheading:18474553-Follow-Up Studies, pubmed-meshheading:18474553-Genes, Viral, pubmed-meshheading:18474553-Genetic Variation, pubmed-meshheading:18474553-HIV Seropositivity, pubmed-meshheading:18474553-HIV-1, pubmed-meshheading:18474553-Human papillomavirus 16, pubmed-meshheading:18474553-Humans, pubmed-meshheading:18474553-Italy, pubmed-meshheading:18474553-Neoplasms, Squamous Cell, pubmed-meshheading:18474553-Oncogene Proteins, Viral, pubmed-meshheading:18474553-Papillomaviridae, pubmed-meshheading:18474553-Papillomavirus E7 Proteins, pubmed-meshheading:18474553-Papillomavirus Infections, pubmed-meshheading:18474553-Polymerase Chain Reaction, pubmed-meshheading:18474553-RNA, Viral, pubmed-meshheading:18474553-Repressor Proteins, pubmed-meshheading:18474553-Risk Assessment, pubmed-meshheading:18474553-Sequence Analysis, pubmed-meshheading:18474553-Uterine Cervical Neoplasms
pubmed:year
2008
pubmed:articleTitle
Human papillomavirus (HPV) genotypes and HPV16 variants in human immunodeficiency virus-positive Italian women.
pubmed:affiliation
Ist Naz. Tumori Fond. G Pascale, Cappella Cangiani, I-80131 Naples, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't