Protein-protein interactions are ubiquitous and essential for all cellular processes. High-resolution X-ray crystallographic structures of protein complexes can reveal the details of their function and provide a basis for many computational and experimental approaches. Differentiation between biological and non-biological contacts and reconstruction of the intact complex is a challenging computational problem. A successful solution can provide additional insights into the fundamental principles of biological recognition and reduce errors in many algorithms and databases utilizing interaction information extracted from the Protein Data Bank (PDB).
Computational Science and Mathematics Division and BioEnergy Science Center, Oak Ridge National Laboratory, PO Box 2008, MS 6173, Oak Ridge, TN 37831, USA. bordner.andrew@mayo.edu
