Source:http://linkedlifedata.com/resource/pubmed/id/18473938
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2008-5-13
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pubmed:abstractText |
We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1389-5575
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-518
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pubmed:meshHeading |
pubmed-meshheading:18473938-Antineoplastic Agents,
pubmed-meshheading:18473938-Cadherins,
pubmed-meshheading:18473938-Gene Expression Regulation,
pubmed-meshheading:18473938-Humans,
pubmed-meshheading:18473938-Neoplasms,
pubmed-meshheading:18473938-Transcription, Genetic,
pubmed-meshheading:18473938-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
E-cadherin upregulation as a therapeutic goal in cancer treatment.
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pubmed:affiliation |
Department of Anatomy, Laboratory Block, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China.
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pubmed:publicationType |
Journal Article,
Review
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