|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0085862,
umls-concept:C0205314,
umls-concept:C0281361,
umls-concept:C0302350,
umls-concept:C0679622,
umls-concept:C1299583,
umls-concept:C1333903,
umls-concept:C1514474,
umls-concept:C1521840,
umls-concept:C1549571,
umls-concept:C1608386
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-7-15
|
|
pubmed:abstractText |
High mobility group AT-hook 1 (HMGA1) proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas. The authors hypothesized that tumor HMGA1 status represents a novel prognostic marker in pancreatic adenocarcinoma. They also tested the hypothesis that HMGA1 promotes anchorage-independent cellular proliferation and in vivo tumorigenicity.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0008-543X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
113
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
302-14
|
|
pubmed:dateRevised |
2011-3-1
|
|
pubmed:meshHeading |
pubmed-meshheading:18473350-Adenocarcinoma,
pubmed-meshheading:18473350-Adult,
pubmed-meshheading:18473350-Aged,
pubmed-meshheading:18473350-Aged, 80 and over,
pubmed-meshheading:18473350-Animals,
pubmed-meshheading:18473350-Cell Line, Tumor,
pubmed-meshheading:18473350-Cell Proliferation,
pubmed-meshheading:18473350-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18473350-Female,
pubmed-meshheading:18473350-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18473350-HMGA1a Protein,
pubmed-meshheading:18473350-Humans,
pubmed-meshheading:18473350-Male,
pubmed-meshheading:18473350-Mice,
pubmed-meshheading:18473350-Mice, Nude,
pubmed-meshheading:18473350-Middle Aged,
pubmed-meshheading:18473350-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:18473350-Pancreatic Neoplasms,
pubmed-meshheading:18473350-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18473350-Prognosis,
pubmed-meshheading:18473350-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18473350-RNA Interference,
pubmed-meshheading:18473350-Survival Rate,
pubmed-meshheading:18473350-Xenograft Model Antitumor Assays
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma.
|
|
pubmed:affiliation |
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
