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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-5-12
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pubmed:abstractText |
Improving outcomes in alcoholic liver disease (ALD) necessitates better understanding of how habitual ethanol (EtOH) consumption alters normal regenerative mechanisms within the liver. Hedgehog (Hh) pathway activation promotes expansion of progenitor populations in other tissues. We evaluated the hypothesis that chronic EtOH exposure activates Hh signaling in liver.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:BrownKevin DKD,
pubmed-author:DiehlAnna MaeAM,
pubmed-author:HinesIan NIN,
pubmed-author:JungYoungmiY,
pubmed-author:MiltonRichard JRJ,
pubmed-author:OmenettiAlessiaA,
pubmed-author:RippeRichard ARA,
pubmed-author:Rubbia-BrandtLauraL,
pubmed-author:SpahrLaurentL,
pubmed-author:VandongenMargonM,
pubmed-author:VoasRR,
pubmed-author:WitekRafal PRP
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pubmed:issnType |
Electronic
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1532-43
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pubmed:meshHeading |
pubmed-meshheading:18471524-Adult,
pubmed-meshheading:18471524-Animals,
pubmed-meshheading:18471524-Biopsy,
pubmed-meshheading:18471524-Cell Count,
pubmed-meshheading:18471524-Cells, Cultured,
pubmed-meshheading:18471524-Central Nervous System Depressants,
pubmed-meshheading:18471524-Disease Models, Animal,
pubmed-meshheading:18471524-Disease Progression,
pubmed-meshheading:18471524-Ethanol,
pubmed-meshheading:18471524-Gene Expression,
pubmed-meshheading:18471524-Hedgehog Proteins,
pubmed-meshheading:18471524-Hepatocytes,
pubmed-meshheading:18471524-Humans,
pubmed-meshheading:18471524-Immunohistochemistry,
pubmed-meshheading:18471524-Ligands,
pubmed-meshheading:18471524-Liver Diseases, Alcoholic,
pubmed-meshheading:18471524-Liver Regeneration,
pubmed-meshheading:18471524-Male,
pubmed-meshheading:18471524-Mice,
pubmed-meshheading:18471524-Middle Aged,
pubmed-meshheading:18471524-Polymerase Chain Reaction,
pubmed-meshheading:18471524-RNA,
pubmed-meshheading:18471524-Severity of Illness Index,
pubmed-meshheading:18471524-Transforming Growth Factor beta1
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pubmed:year |
2008
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pubmed:articleTitle |
Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans.
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pubmed:affiliation |
Department of Medicine, Duke University, Durham, North Carolina.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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