Source:http://linkedlifedata.com/resource/pubmed/id/18471445
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2008-5-12
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| pubmed:abstractText |
To evaluate survival after acute myocardial infarction (AMI) in nonagenarians, we conducted a retrospective chart review of 177 consecutive patients > or =90 years of age admitted from 2000 to 2006 with a primary diagnosis of AMI confirmed by peak troponin I > or =1.5 microg/L. Mean follow-up was 3.7 years (range 4 months to 6.7 years). Mean age was 93 years, 34% were men, and 60% were Caucasian. Common co-morbidities included hypertension (67%), dyslipidemia (28%), atrial fibrillation (28%), renal insufficiency (27%), dementia (23%), and previous cerebrovascular events (22%). Mean peak troponin was 20 mug/L (range 1.5 to 183 microg/L). Cardiac catheterization was performed within 48 hours in 42 patients (24%) and after 48 hours in 14 patients (8%); 40 patients (23%) received an intervention. Hospital mortality was 15% (n = 27). Survival at 30 days, 90 days, and 1 year were 78%, 69%, and 47%. Independent predictors of shorter survival time by Cox analysis included body mass index <25 kg/m2 (p <0.001), creatinine > or =2.0 mg/dl (p = 0.001), hemoglobin <11.0 g/dl (p = 0.016), and dementia (p = 0.027). Patients receiving aspirin, clopidogrel, beta blockers, and renin-angiotensin system inhibitors appeared to have a lower mortality. In conclusion, AMI in nonagenarians is associated with high mortality, with over 50% of patients dying within one year of presentation; elevated creatinine and lower hemoglobin are strong predictors of adverse prognosis, and lower body mass index and the presence of dementia add independent prognostic significance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
101
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1379-83
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| pubmed:meshHeading |
pubmed-meshheading:18471445-Adrenergic beta-Antagonists,
pubmed-meshheading:18471445-Aged, 80 and over,
pubmed-meshheading:18471445-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:18471445-Drug Therapy, Combination,
pubmed-meshheading:18471445-Electrocardiography,
pubmed-meshheading:18471445-Female,
pubmed-meshheading:18471445-Follow-Up Studies,
pubmed-meshheading:18471445-Heart Catheterization,
pubmed-meshheading:18471445-Hospital Mortality,
pubmed-meshheading:18471445-Humans,
pubmed-meshheading:18471445-Male,
pubmed-meshheading:18471445-Missouri,
pubmed-meshheading:18471445-Myocardial Infarction,
pubmed-meshheading:18471445-Platelet Aggregation Inhibitors,
pubmed-meshheading:18471445-Prognosis,
pubmed-meshheading:18471445-Retrospective Studies,
pubmed-meshheading:18471445-Risk Factors,
pubmed-meshheading:18471445-Survival Rate,
pubmed-meshheading:18471445-Time Factors
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Outcomes of acute myocardial infarction in nonagenarians.
|
| pubmed:affiliation |
Department of Internal Medicine, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, Missouri, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|