| pubmed-article:18470577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C0039508 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C0015672 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:18470577 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:18470577 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18470577 | pubmed:dateCreated | 2008-6-11 | lld:pubmed |
| pubmed-article:18470577 | pubmed:abstractText | Mechanical overloading is a major causative factor of tendinopathy; however, its underlying mechanisms are unclear. We hypothesized mechanical overloading would damage tendons and alter genes associated with tendinopathy in a load-dependent manner. To test this hypothesis, we fatigue loaded rat patellar tendons in vivo and measured expression of the matrix-degrading enzyme MMP-13 and the inflammatory cytokine IL-1beta. We also examined these responses in cultured tenocytes exposed to intermittent hydrostatic pressure in vitro. Additionally, we hypothesized load-induced changes in tenocyte MMP-13 expression would be dependent on expression of IL-1beta. In vivo fatigue loading at 1.7% strain caused overt microstructural damage and upregulated expression of MMP-13 and IL-1beta, while 0.6% strain produced only minor changes in matrix microstructure and downregulated expression of both MMP-13 and IL-1beta. Loading of cultured tenocytes at 2.5 and 7.5 MPa produced comparable changes in expression to those of in vivo tendon loading. Blocking IL-1beta expression with siRNA suppressed load-induced both MMP-13 mRNA expression and activity. The data suggest fatigue loading alters expression of MMP-13 and IL-1beta in tendons in vivo and tenocytes in vitro in a load-dependent manner. The data also suggest MMP-13 is regulated by both IL-1beta-dependent and IL-1beta-independent pathways. | lld:pubmed |
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| pubmed-article:18470577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18470577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18470577 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18470577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18470577 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18470577 | pubmed:issn | 1528-1132 | lld:pubmed |
| pubmed-article:18470577 | pubmed:author | pubmed-author:FlatowEvan... | lld:pubmed |
| pubmed-article:18470577 | pubmed:author | pubmed-author:MajeskaRobert... | lld:pubmed |
| pubmed-article:18470577 | pubmed:author | pubmed-author:SchafflerMitc... | lld:pubmed |
| pubmed-article:18470577 | pubmed:author | pubmed-author:LiYonghuiY | lld:pubmed |
| pubmed-article:18470577 | pubmed:author | pubmed-author:FungDavid TDT | lld:pubmed |
| pubmed-article:18470577 | pubmed:author | pubmed-author:SunHui BHB | lld:pubmed |
| pubmed-article:18470577 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18470577 | pubmed:volume | 466 | lld:pubmed |
| pubmed-article:18470577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18470577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18470577 | pubmed:pagination | 1555-61 | lld:pubmed |
| pubmed-article:18470577 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18470577 | pubmed:meshHeading | pubmed-meshheading:18470577... | lld:pubmed |
| pubmed-article:18470577 | pubmed:meshHeading | pubmed-meshheading:18470577... | lld:pubmed |
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| pubmed-article:18470577 | pubmed:meshHeading | pubmed-meshheading:18470577... | lld:pubmed |
| pubmed-article:18470577 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18470577 | pubmed:articleTitle | Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage. | lld:pubmed |
| pubmed-article:18470577 | pubmed:affiliation | Leni and Peter May Department of Orthopaedics, Mount Sinai School of Medicine, 5 East 98th Street, 9th Floor, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:18470577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18470577 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18470577 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18470577 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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