| pubmed-article:18469066 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0034821 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C1417947 | lld:lifeskim |
| pubmed-article:18469066 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:18469066 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18469066 | pubmed:dateCreated | 2008-8-19 | lld:pubmed |
| pubmed-article:18469066 | pubmed:abstractText | The lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) expressed on vascular cells plays a major role in atherogenesis by internalizing and degrading oxidized low-density lipoprotein. LOX-1 can be cleaved from the cell surface and released as soluble LOX-1 (sLOX-1), and elevated sLOX-1 levels may be indicative of atherosclerotic plaque instability. We examined associations between the LOX-1 gene 3'UTR-C/T and G501C polymorphisms and plasma sLOX-1 levels in 97 healthy older men and women. The frequencies for the 3'UTR-T and 501C alleles were 46 and 10%, respectively. Plasma sLOX-1 levels were significantly higher in the 3'UTR CC genotype group compared with both the CT (P=0.02) and TT genotype groups (P=0.002). Plasma sLOX-1 levels were also significantly higher in the 501GC genotype group compared with the GG genotype group (P=0.004). In univariate analyses, sLOX-1 levels were significantly associated with both the 3'UTR-C/T and G501C polymorphisms. These associations remained significant after adjusting for age, sex, race and body mass index. In conclusion, variation in the LOX-1 gene is associated with plasma sLOX-1 levels in older men and women. | lld:pubmed |
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| pubmed-article:18469066 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18469066 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18469066 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18469066 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18469066 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18469066 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18469066 | pubmed:issn | 0958-0670 | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:KumeNoriakiN | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:KitaToruT | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:BrownMichael... | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:HagbergJames... | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:FerrellRobert... | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:PharesDana... | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:MitsuokaHirok... | lld:pubmed |
| pubmed-article:18469066 | pubmed:author | pubmed-author:BrinkleyTina... | lld:pubmed |
| pubmed-article:18469066 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18469066 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:18469066 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18469066 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18469066 | pubmed:pagination | 1085-90 | lld:pubmed |
| pubmed-article:18469066 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:18469066 | pubmed:meshHeading | pubmed-meshheading:18469066... | lld:pubmed |
| pubmed-article:18469066 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18469066 | pubmed:articleTitle | Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels. | lld:pubmed |
| pubmed-article:18469066 | pubmed:affiliation | Department of Kinesiology, University of Maryland, College Park, MD 20742, USA. tiellis@wfubmc.edu | lld:pubmed |
| pubmed-article:18469066 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18469066 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18469066 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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