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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-8-19
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pubmed:abstractText |
The lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) expressed on vascular cells plays a major role in atherogenesis by internalizing and degrading oxidized low-density lipoprotein. LOX-1 can be cleaved from the cell surface and released as soluble LOX-1 (sLOX-1), and elevated sLOX-1 levels may be indicative of atherosclerotic plaque instability. We examined associations between the LOX-1 gene 3'UTR-C/T and G501C polymorphisms and plasma sLOX-1 levels in 97 healthy older men and women. The frequencies for the 3'UTR-T and 501C alleles were 46 and 10%, respectively. Plasma sLOX-1 levels were significantly higher in the 3'UTR CC genotype group compared with both the CT (P=0.02) and TT genotype groups (P=0.002). Plasma sLOX-1 levels were also significantly higher in the 501GC genotype group compared with the GG genotype group (P=0.004). In univariate analyses, sLOX-1 levels were significantly associated with both the 3'UTR-C/T and G501C polymorphisms. These associations remained significant after adjusting for age, sex, race and body mass index. In conclusion, variation in the LOX-1 gene is associated with plasma sLOX-1 levels in older men and women.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-10330129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-10377073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-10712396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-11423119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-11507327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-1192594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-12163130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-12646194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-12810610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-14684693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-15562935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-15976314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-16061745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-16251892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-16324688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-16829343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-17022953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-17321727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-1752940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-2349926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-4337382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-4818200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-7074948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-8772476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18469066-9052782
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0958-0670
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1085-90
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18469066-Age Factors,
pubmed-meshheading:18469066-Aged,
pubmed-meshheading:18469066-Atherosclerosis,
pubmed-meshheading:18469066-Exons,
pubmed-meshheading:18469066-Female,
pubmed-meshheading:18469066-Gene Frequency,
pubmed-meshheading:18469066-Genetic Testing,
pubmed-meshheading:18469066-Genotype,
pubmed-meshheading:18469066-Humans,
pubmed-meshheading:18469066-Male,
pubmed-meshheading:18469066-Middle Aged,
pubmed-meshheading:18469066-Polymorphism, Single Nucleotide,
pubmed-meshheading:18469066-Scavenger Receptors, Class E
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pubmed:year |
2008
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pubmed:articleTitle |
Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels.
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pubmed:affiliation |
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA. tiellis@wfubmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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