|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0025260,
umls-concept:C0037354,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0301508,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-5-16
|
|
pubmed:abstractText |
To explore the human T cell response to acute viral infection, we performed a longitudinal analysis of CD8(+) T cells responding to the live yellow fever virus and smallpox vaccines--two highly successful human vaccines. Our results show that both vaccines generated a brisk primary effector CD8(+) T cell response of substantial magnitude that could be readily quantitated with a simple set of four phenotypic markers. Secondly, the vaccine-induced T cell response was highly specific with minimal bystander effects. Thirdly, virus-specific CD8(+) T cells passed through an obligate effector phase, contracted more than 90% and gradually differentiated into long-lived memory cells. Finally, these memory cells were highly functional and underwent a memory differentiation program distinct from that described for human CD8(+) T cells specific for persistent viruses. These results provide a benchmark for CD8(+) T cell responses induced by two of the most effective vaccines ever developed.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1097-4180
|
|
pubmed:author |
pubmed-author:AhmedRafiR,
pubmed-author:AkondyRama SRS,
pubmed-author:AlbottSophiaS,
pubmed-author:AltmanJohn DJD,
pubmed-author:Del RioCarlosC,
pubmed-author:EdupugantiSrilathaS,
pubmed-author:FeinbergMark BMB,
pubmed-author:GermonStephanieS,
pubmed-author:GlidewellJohn TJT,
pubmed-author:LalorSusanS,
pubmed-author:MaharPatryce LPL,
pubmed-author:MasopustDavidD,
pubmed-author:MillerJoseph DJD,
pubmed-author:MulliganMark JMJ,
pubmed-author:Murali-KrishnaKajaK,
pubmed-author:StapransSilvija ISI,
pubmed-author:van der MostRobbert GRG
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
710-22
|
|
pubmed:dateRevised |
2009-5-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18468462-B-Lymphocytes,
pubmed-meshheading:18468462-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18468462-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18468462-Histocompatibility Antigens Class I,
pubmed-meshheading:18468462-Humans,
pubmed-meshheading:18468462-Immunologic Memory,
pubmed-meshheading:18468462-Lymphocyte Activation,
pubmed-meshheading:18468462-Smallpox Vaccine,
pubmed-meshheading:18468462-T-Lymphocyte Subsets,
pubmed-meshheading:18468462-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:18468462-Vaccination,
pubmed-meshheading:18468462-Vaccinia virus,
pubmed-meshheading:18468462-Yellow Fever Vaccine
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.
|
|
pubmed:affiliation |
Emory Vaccine Center and the Hope Clinic, Emory University School of Medicine, Atlanta, GA 30322, USA.
|
|
pubmed:publicationType |
Journal Article
|
