|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2008-5-9
|
|
pubmed:abstractText |
The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias. Cytogenetic and molecular analyses revealed a normal karyotype (2n = 78,XY) and the presence of SRY, INSL3 and RXFP2 genes with a normal DNA sequence for SRY and RXFP2, while the INSL3 sequence differed slightly from the normal one due to a heterozygous nucleotide change involving amino acid 22 of the INSL3 dog precursor protein. Levels of plasmatic testosterone were only 0.01 ng/ml, while FSH and LH serum levels were not detectable. After the human chorionic gonadotropin (hCG) test, the serum testosterone level was 0.01 ng/ml. Therefore, the phenotypic aetiology of this subject can not be well-defined because cryptorchidism and hypospadias were frequent clinical features with high genetic heterogeneity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1424-859X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
120
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
140-3
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:18467838-Amino Acid Sequence,
pubmed-meshheading:18467838-Amino Acid Substitution,
pubmed-meshheading:18467838-Animals,
pubmed-meshheading:18467838-Base Sequence,
pubmed-meshheading:18467838-Cryptorchidism,
pubmed-meshheading:18467838-DNA Primers,
pubmed-meshheading:18467838-Dog Diseases,
pubmed-meshheading:18467838-Dogs,
pubmed-meshheading:18467838-Genes, sry,
pubmed-meshheading:18467838-Hypospadias,
pubmed-meshheading:18467838-Insulin,
pubmed-meshheading:18467838-Karyotyping,
pubmed-meshheading:18467838-Male,
pubmed-meshheading:18467838-Molecular Sequence Data,
pubmed-meshheading:18467838-Phenotype,
pubmed-meshheading:18467838-Point Mutation,
pubmed-meshheading:18467838-Prognosis,
pubmed-meshheading:18467838-Proteins,
pubmed-meshheading:18467838-Receptors, G-Protein-Coupled,
pubmed-meshheading:18467838-Sequence Homology, Amino Acid,
pubmed-meshheading:18467838-Species Specificity
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias.
|
|
pubmed:affiliation |
Physiopathology and Reproduction, Faculty of Veterinary Medicine, University 'Federico II', Naples, Italy.
|
|
pubmed:publicationType |
Journal Article,
Case Reports
|
