|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2008-5-9
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|
pubmed:abstractText |
There are no accurate prognostic biomarkers specific for rectal cancer. Epigenetic aberrations, in the form of DNA methylation, accumulate early during rectal tumor formation. In a preliminary study, we investigated absolute quantitative methylation changes associated with tumor progression of rectal tissue at multiple genomic methylated-in-tumor (MINT) loci sequences. We then explored in a different clinical patient group whether these epigenetic changes could be correlated with clinical outcome.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1527-7755
|
|
pubmed:author |
pubmed-author:BilchikAntonA,
pubmed-author:HoonDave S BDS,
pubmed-author:Klein-KranenbargElma MeershoekEM,
pubmed-author:PutterHeinH,
pubmed-author:TollenaarRob A E MRA,
pubmed-author:TurnerRoderick RRR,
pubmed-author:UmetaniNaoyukiN,
pubmed-author:de MaatMichiel F GMF,
pubmed-author:van KriekenJ Han J MJH,
pubmed-author:van de VeldeCornelis J HCJ,
pubmed-author:van der WerffMartijn P JMP
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
10
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2327-35
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Quantitative analysis of methylation of genomic loci in early-stage rectal cancer predicts distant recurrence.
|
|
pubmed:affiliation |
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA.
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|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
