Source:http://linkedlifedata.com/resource/pubmed/id/18467645
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2008-7-24
|
| pubmed:abstractText |
Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular inflammation, fibrosis, and remodeling. Molecular mechanisms underlying this are unclear. We tested the hypothesis that c-Src activation, through receptor tyrosine kinase transactivation, is critically involved in synergistic interactions between Aldo and Ang II and that it is upstream of promigratory signaling pathways in vascular smooth muscle cells (VSMCs).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1524-4636
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1511-8
|
| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18467645-Aldosterone,
pubmed-meshheading:18467645-Angiotensin II,
pubmed-meshheading:18467645-Animals,
pubmed-meshheading:18467645-Cell Movement,
pubmed-meshheading:18467645-Cells, Cultured,
pubmed-meshheading:18467645-Male,
pubmed-meshheading:18467645-Muscle, Smooth, Vascular,
pubmed-meshheading:18467645-Myocytes, Smooth Muscle,
pubmed-meshheading:18467645-Rats,
pubmed-meshheading:18467645-Signal Transduction,
pubmed-meshheading:18467645-rhoA GTP-Binding Protein,
pubmed-meshheading:18467645-src-Family Kinases
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways.
|
| pubmed:affiliation |
Ottawa Health Research Institute, University of Ottawa, 451 Smyth Road, Ottawa, K1H 8M5, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article
|