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rdf:type |
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|
lifeskim:mentions |
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|
pubmed:issue |
4995
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pubmed:dateCreated |
1991-3-7
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|
pubmed:abstractText |
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Feb
|
|
pubmed:issn |
0036-8075
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
15
|
|
pubmed:volume |
251
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
802-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1846706-Cell Line,
pubmed-meshheading:1846706-Cross-Linking Reagents,
pubmed-meshheading:1846706-Growth Substances,
pubmed-meshheading:1846706-Hepatocyte Growth Factor,
pubmed-meshheading:1846706-Humans,
pubmed-meshheading:1846706-Molecular Weight,
pubmed-meshheading:1846706-Phosphorylation,
pubmed-meshheading:1846706-Precipitin Tests,
pubmed-meshheading:1846706-Protein-Tyrosine Kinases,
pubmed-meshheading:1846706-Proto-Oncogene Proteins,
pubmed-meshheading:1846706-Proto-Oncogene Proteins c-met,
pubmed-meshheading:1846706-Receptors, Cell Surface
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
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|
pubmed:affiliation |
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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