Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-9
pubmed:abstractText
Three LOD score statistics are often used for genome-wide linkage analysis: the maximum LOD score, the LOD score statistic proposed by Kong and Cox, both based on the allele-sharing between affected sib pairs, and the maximization of the LOD score function of Morton on two genetic models and an heterogeneity parameter.Using only identity-by-descent sharing between affected sibs as linkage information, we studied the behavior of these three statistics under the null hypothesis in the rheumatoid arthritis simulated data (Genetic Analysis Workshop 15 Problem 3 - simulating model known). Distributions under the null hypothesis show that identical values of the statistics correspond to very different genome-wide p-values: comparison and interpretation of several linkage statistics cannot be done on the observed value. The Kong and Cox LOD score statistic had slightly better power to detect the HLA region involved in rheumatoid arthritis compared to the other methods. In a second step, we show that performing the analysis under a greater number of genetic models in the hope of better scanning the space of models, does not increase the power of detection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-10802644, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-10884360, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-11037317, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-11526246, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-12679476, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-13258560, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-14758336, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-15273935, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-2301394, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-3741977, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-7668271, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-8430697, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-8651312, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-9345087, http://linkedlifedata.com/resource/pubmed/commentcorrection/18466442-9718328
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1753-6561
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S102
pubmed:year
2007
pubmed:articleTitle
On the choice of linkage statistics.
pubmed:affiliation
INSERM U535, F-94817 Villejuif, France. jeannin@vjf.inserm.fr
pubmed:publicationType
Journal Article