Linked Life Data

18466051

Source:http://linkedlifedata.com/resource/pubmed/id/18466051

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-5-9
pubmed:abstractText
In recent years, a large number of proteomics studies for various diseases were conducted, such as for cancer, cardiovascular and neurodegenerative disorders (NDs). The availability of huge data sets with a large number of differentially expressed proteins showed for the first time that not all protein changes between a diseased and a control state were specific. This review focuses on this protein expression overlap, specifically between NDs, and tries to investigate the possible reasons for this overlap by investigating 14 ND proteomics studies of Alzheimer's (six studies), Parkinson's (four studies) and Huntington's disease (three studies), as well as amyotrophic lateral sclerosis (one study). Studies were selected according to the availability of quantitative changes, number of (biological) repeats and numbers of proteins changed. The studies include investigations of human tissue and mouse, as well as cell culture, models. A change in metabolism-related proteins was found to be common among all disorders. These changes can be explained by alterations in key regulatory proteins, such as those involved in transcription. Since most NDs affect, at least initially, very specific areas of the brain, the location of the changes may be more important than the kind of protein alterations that occur, since they are very similar among NDs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1744-8387
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-205
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Protein expression overlap: more important than which proteins change in expression?
pubmed:affiliation
Institute for Human Genetics, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. claus.zabel@charite.de
pubmed:publicationType
Journal Article, Review