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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-22
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pubmed:abstractText |
Activation of a phosphatidylinositol-3-kinase (PI-3-kinase) is one of the earliest consequences of insulin binding to the receptor. The human insulin receptor exists in two isoforms which differ in the length of the alpha-subunit (HIR-A = 719 aa, HIR-B = 731 aa). To test whether both isoforms transduce an insulin signal on PI-3-kinase we used rat-1-fibroblasts expressing HIR-A or HIR-B. We found that insulin stimulates 32P incorporation into PIP through both HIR-A and HIR-B to a similar extent (approx. 8-10 fold).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1846534-Animals,
pubmed-meshheading:1846534-Cells, Cultured,
pubmed-meshheading:1846534-Enzyme Activation,
pubmed-meshheading:1846534-Humans,
pubmed-meshheading:1846534-Insulin,
pubmed-meshheading:1846534-Isoenzymes,
pubmed-meshheading:1846534-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:1846534-Phosphotransferases,
pubmed-meshheading:1846534-Rats,
pubmed-meshheading:1846534-Receptor, Insulin
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pubmed:year |
1991
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pubmed:articleTitle |
Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types.
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pubmed:affiliation |
Institut für Diabetesforschung, München, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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