Source:http://linkedlifedata.com/resource/pubmed/id/18464616
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2008-5-9
|
pubmed:abstractText |
Integrin alphaIIbbeta3 of the platelet surfaces regulates the thrombosis formation. alphaIIbbeta3 binds to the RGD sequence (Arg-Gly-Asp) of fibrinogen, promotes the platelet aggregation and finally leads to the thrombus. We obtained the three-dimensional molecular structure of alphaIIbbeta3 using homology-modeling (modeller8v2 software), with integrin alphavbeta3 (pdb code 1JV2) as the template. Accordingly, a cyclic RGD(RGD-c) peptide was designed to bind alphaIIbbeta3 as an antagonist and to block the formation of thrombus. We added two amino acids X, Y to both sides of RGD-c. X and Y could bind to each other by disulfide bond that finally made RGD-c a cyclic peptide. The optimum structure of RGD-c was obtained from the energetic optimization processes. All amino acids were placed at the X and Y to conduct Molecular Docking to the integrin alphaIIbbeta3 We got the optimum structure of RGD-c by energetic optimization and the antagonistic combination analysis. The results might provide an insight into designing and screening integrin alphaIIbbeta3 antagonists.
|
pubmed:language |
chi
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Glycoprotein GPIIb-IIIa...,
http://linkedlifedata.com/resource/pubmed/chemical/arginyl-glycyl-aspartic acid
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1000-3061
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
297-301
|
pubmed:meshHeading |
pubmed-meshheading:18464616-Amino Acid Sequence,
pubmed-meshheading:18464616-Drug Design,
pubmed-meshheading:18464616-Humans,
pubmed-meshheading:18464616-Models, Molecular,
pubmed-meshheading:18464616-Oligopeptides,
pubmed-meshheading:18464616-Platelet Aggregation Inhibitors,
pubmed-meshheading:18464616-Platelet Glycoprotein GPIIb-IIIa Complex
|
pubmed:year |
2008
|
pubmed:articleTitle |
[alphaIIbbeta3 modeling simulation and design of the cyclic RGD].
|
pubmed:affiliation |
College of Physics, Nankai University, Tianjin 300071, China.
|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|