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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2008-8-6
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pubmed:abstractText |
Multimodality treatments that combine conventional cancer therapies with antigen-specific immunotherapy have emerged as promising approaches for the control of cancer. In the current study, we have explored the effect of doxorubicin on the antigen-specific immune responses generated in mice vaccinated with calreticulin (CRT)/E6 and/or Ii-PADRE DNA. We observed that pretreatment with doxorubicin suppressed the E6-specific CD8+ T-cell immune responses generated by CRT/E6 DNA vaccination in vaccinated mice. In contrast, pretreatment with doxorubicin enhanced the PADRE-specific CD4+ T-cell immune responses generated by Ii-PADRE DNA vaccination. Furthermore, coadministration of Ii-PADRE DNA could not only reverse the suppression, but also enhanced the E6-specific CD8+ T-cell responses in CRT/E6-vaccinated mice pretreated with doxorubicin. Finally, treatment with doxorubicin followed by CRT/E6 combined with Ii-PADRE DNA vaccination led to enhanced antitumor effects and prolonged survival in TC-1 tumor-bearing mice. The clinical implications of the current study are discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-10706121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-10837079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-11325840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-12669466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-15280455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-15474971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-16166275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-16177818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-16551258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17234792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17356542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17408372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17591836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17915300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17919349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17949799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17973267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-17981543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-18043124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-18077994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-18273057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-5772652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-7969078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-8548765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18463686-9000640
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1476-5462
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1176-83
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:18463686-Animals,
pubmed-meshheading:18463686-Antigen Presentation,
pubmed-meshheading:18463686-Biolistics,
pubmed-meshheading:18463686-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18463686-Calreticulin,
pubmed-meshheading:18463686-Cancer Vaccines,
pubmed-meshheading:18463686-Combined Modality Therapy,
pubmed-meshheading:18463686-Dendritic Cells,
pubmed-meshheading:18463686-Doxorubicin,
pubmed-meshheading:18463686-Female,
pubmed-meshheading:18463686-Gene Therapy,
pubmed-meshheading:18463686-Immunosuppressive Agents,
pubmed-meshheading:18463686-Immunotherapy, Active,
pubmed-meshheading:18463686-Lymphocyte Activation,
pubmed-meshheading:18463686-Malaria Vaccines,
pubmed-meshheading:18463686-Mice,
pubmed-meshheading:18463686-Mice, Inbred C57BL,
pubmed-meshheading:18463686-Neoplasms,
pubmed-meshheading:18463686-Oncogene Proteins, Viral,
pubmed-meshheading:18463686-Xenograft Model Antitumor Assays
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pubmed:year |
2008
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pubmed:articleTitle |
Enhancement of CD4+ T-cell help reverses the doxorubicin-induced suppression of antigen-specific immune responses in vaccinated mice.
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pubmed:affiliation |
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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