Linked Life Data

18463243

Source:http://linkedlifedata.com/resource/pubmed/id/18463243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2008-5-8
pubmed:abstractText
Schizophrenia impairs many cognitive functions, and abnormalities in language processing have been proposed as one of the bases for this disorder. Previously, it was reported that different magnetoencephalography (MEG) patterns of the evoked oscillatory activity (eOA) of 20-45 Hz to speech and nonspeech sounds were evidence of a fast mechanism for the representation and identification of speech sounds in humans. The current study tested the hypothesis that the schizophrenics would show abnormal neural oscillatory activity, as measured by eOA, to speech and nonspeech sounds. Twenty patients and 23 control subjects participated in this study. MEG responses to speech and nonspeech sounds were recorded and eOA power and phase locking at 20-45 Hz were analyzed. Patients showed significantly delayed peak latencies of the eOA power and phase locking to speech sounds in the left hemisphere and to nonspeech sounds in the right hemisphere. Patients also showed a significantly reduced eOA power to speech sounds in the left hemisphere in 0-50 ms and a significantly larger eOA power to speech sounds in the left hemisphere in 100-150 ms. In addition, the analyses of the lateralization index revealed the pattern of hemispheric lateralization to be the opposite in patients. These results indicated that patients showed different characteristics of eOA compared with normal controls, probably related to deficits in a fast mechanism for identifying speech sounds. Moreover, the present study suggests that schizophrenia might be characterized by an opposite pattern of hemispheric lateralization in auditory evoked oscillations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4897-903
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Abnormal neural oscillatory activity to speech sounds in schizophrenia: a magnetoencephalography study.
pubmed:affiliation
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't