Linked Life Data

184628

Source:http://linkedlifedata.com/resource/pubmed/id/184628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1976-11-21
pubmed:abstractText
The development of aryl hydrocarbon (benzo(a)pyren)hydroxylase (AHH), succinate dehydrogenase and glucose-b-phosphatase activities in the liver and the kidney and of liver weight and glycogen were investigated in 7-day-old rats treated i.p. with 1, 10, and 100 mg 3-methylcholanthrene (MC)/kg body weight. 3-MC highly specifically influenced the AHH activity, which was increased dose dependent. The higher the dose, the higher and the longer was the induction effect. The other biochemical parameters investigated were not influenced. At the maximum of the induction effect after pretreatment with the highest dose of 3MC no morphological alterations in the liver could be observed by light and electron microscopy. Therefore the 3-MC mediated AHH induction seems to be a suitable model for the examination of dose dependent inducer-inhibitor interactions in the intact animal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5318
pubmed:author
pubmed:issnType
Print
pubmed:volume
34?710
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1701-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
On the selectivity of aryl hydrocarbon hydroxylase induction after 3-methylcholanthrene pretreatment.
pubmed:publicationType
Journal Article