Source:http://linkedlifedata.com/resource/pubmed/id/18461559
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2009-2-9
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pubmed:abstractText |
Rats were treated by gavage once daily with 2,4-dinitrophenol (DNP) at 0 (control), 3, 10, or 30 mg/kg bw. Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40-47 days, from 14 days before mating to day 3 of lactation. No deaths were observed in males and females of any group. A significant decrease in body weight gain and significant increase in liver weight were found in males and females at 30 mg/kg bw/day. The number of live pups on postnatal days (PNDs) 0 and 4, live birth index, and body weight of live male and female pups on PNDs 0 and 1 were significantly lowered at 30 mg/kg bw/day. External and internal examinations of pups revealed no increased incidence of malformations in DNP-treated groups. On the basis of these findings, we concluded that DNP has general and reproductive/developmental toxicity, but not teratogenicity, under the present conditions. The NOAEL of DNP is considered to be 10 mg/kg bw/day in rats.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1522-7278
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-81
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pubmed:meshHeading |
pubmed-meshheading:18461559-2,4-Dinitrophenol,
pubmed-meshheading:18461559-Abnormalities, Drug-Induced,
pubmed-meshheading:18461559-Animals,
pubmed-meshheading:18461559-Animals, Newborn,
pubmed-meshheading:18461559-Body Weight,
pubmed-meshheading:18461559-Female,
pubmed-meshheading:18461559-Liver,
pubmed-meshheading:18461559-Male,
pubmed-meshheading:18461559-Organ Size,
pubmed-meshheading:18461559-Pregnancy,
pubmed-meshheading:18461559-Rats,
pubmed-meshheading:18461559-Reproduction
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pubmed:year |
2009
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pubmed:articleTitle |
Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats.
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pubmed:affiliation |
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo 158-8501, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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