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18461292

Source:http://linkedlifedata.com/resource/pubmed/id/18461292

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pubmed-article:18461292pubmed:abstractTextIt is considered that the mechanism in intractable cutaneous ulcer is deeply associated with prolongation at the inflammatory phase. Having evaluated the effects of Lipo-prostaglandin E1 (Lipo-PGE1) with indicators such as the reduction ratio of the ulcer area and the values of the inflammatory markers after dividing them into two groups of collagen diseases and non-collagen diseases and giving them Lipo-PGE1, we managed to obtain the result that Lipo-PGE1 administration could influence various inflammatory markers such as C-reactive protein (CRP), IL-6, and VEGF in addition to reduction of the ulcer region. It also suggested that Lipo-PGE1 has the effect of maintaining an appropriate balance of induction of inflammation and angiogenesis. Additionally, it revealed that Lipo-PGE1 controls the production of cytokines, which are associated with the growth of collagen diseases. From these results, it can be expected that Lipo-PGE1 will act favorably on intractable collagen diseases.lld:pubmed
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pubmed-article:18461292pubmed:articleTitleNew aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer.lld:pubmed
pubmed-article:18461292pubmed:affiliationDepartment of Dermatology Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita City, Osaka 565-0871, Japan. h-murota@derma.med.osaka-u.ac.jplld:pubmed
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