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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-8-12
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pubmed:abstractText |
It is considered that the mechanism in intractable cutaneous ulcer is deeply associated with prolongation at the inflammatory phase. Having evaluated the effects of Lipo-prostaglandin E1 (Lipo-PGE1) with indicators such as the reduction ratio of the ulcer area and the values of the inflammatory markers after dividing them into two groups of collagen diseases and non-collagen diseases and giving them Lipo-PGE1, we managed to obtain the result that Lipo-PGE1 administration could influence various inflammatory markers such as C-reactive protein (CRP), IL-6, and VEGF in addition to reduction of the ulcer region. It also suggested that Lipo-PGE1 has the effect of maintaining an appropriate balance of induction of inflammation and angiogenesis. Additionally, it revealed that Lipo-PGE1 controls the production of cytokines, which are associated with the growth of collagen diseases. From these results, it can be expected that Lipo-PGE1 will act favorably on intractable collagen diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0172-8172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1127-35
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pubmed:meshHeading |
pubmed-meshheading:18461292-Adult,
pubmed-meshheading:18461292-Aged,
pubmed-meshheading:18461292-Aged, 80 and over,
pubmed-meshheading:18461292-Alprostadil,
pubmed-meshheading:18461292-Anti-Inflammatory Agents,
pubmed-meshheading:18461292-C-Reactive Protein,
pubmed-meshheading:18461292-Cohort Studies,
pubmed-meshheading:18461292-Collagen Diseases,
pubmed-meshheading:18461292-Female,
pubmed-meshheading:18461292-Humans,
pubmed-meshheading:18461292-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18461292-Interleukin-6,
pubmed-meshheading:18461292-Male,
pubmed-meshheading:18461292-Middle Aged,
pubmed-meshheading:18461292-Rheumatic Diseases,
pubmed-meshheading:18461292-Skin Ulcer,
pubmed-meshheading:18461292-Vascular Endothelial Growth Factor A
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pubmed:year |
2008
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pubmed:articleTitle |
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer.
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pubmed:affiliation |
Department of Dermatology Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita City, Osaka 565-0871, Japan. h-murota@derma.med.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article
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