Linked Life Data

18460886

Source:http://linkedlifedata.com/resource/pubmed/id/18460886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-7
pubmed:abstractText
Pemphigus foliaceus (PF) and its endemic form fogo selvagem (FS) are autoimmune diseases characterized clinically by transient cutaneous superficial blisters. As opposed to pemphigus vulgaris (PV), patients lack mucosal involvement. Acantholysis in the upper epidermis is appreciated histologically. The serologic hallmark of PF and FS is the demonstration of IgG autoantibodies against the cell surface of keratinocytes. The specific target of these autoantibodies is desmoglein (Dsg) 1, one of the four known desmosomal cadherins, a family of transmembrane glycoproteins that play an important role in the dynamic regulation of intercellular adhesion. Compelling evidence has been compiled suggesting anti-Dsg1 autoantibodies in patients with PF and FS are pathogenic. The mechanism by which anti-Dsg autoantibodies induce loss of cell-cell adhesion in PF is under active investigation and is beginning to be elucidated. The study of the pathogenesis of PF and FS provides a unique opportunity to uncover insights that may contribute to our greater understanding of autoimmunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1422-2132
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
182-94
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Pemphigus foliaceus.
pubmed:affiliation
Department of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
pubmed:publicationType
Journal Article, Review