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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-5-7
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pubmed:abstractText |
Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis induced by AMP-activated protein kinase (AMPK) resulting in decreased hypothalamic levels of malonyl-CoA and increased carnitine palmitoyltransferase 1 (CPT1) activity. In addition, we also demonstrate that fasting downregulates fatty acid synthase (FAS) in a region-specific manner and that this effect is mediated by an AMPK and ghrelin-dependent mechanisms. Thus, decreasing AMPK activity in the ventromedial nucleus of the hypothalamus (VMH) is sufficient to inhibit ghrelin's effects on FAS expression and feeding. Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AMP-activated protein kinase kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Carnitine O-Palmitoyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Fas protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Synthetase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Ghrelin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Malonyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1932-7420
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pubmed:author |
pubmed-author:AlvarezClara VCV,
pubmed-author:CarlingDavidD,
pubmed-author:CastañedaTamaraT,
pubmed-author:CullerMichaelM,
pubmed-author:DattaRakeshR,
pubmed-author:DeoliveiraRosangela MRM,
pubmed-author:DiéguezCarlosC,
pubmed-author:DongJesse ZJZ,
pubmed-author:GallegoRosalíaR,
pubmed-author:LópezMiguelM,
pubmed-author:LageRicardoR,
pubmed-author:LelliottChristopher JCJ,
pubmed-author:Pérez-TilveDiegoD,
pubmed-author:RaghayKawtarK,
pubmed-author:Rodríguez-CuencaSergioS,
pubmed-author:SahaAsish KAK,
pubmed-author:Sangiao-AlvarellosSusanaS,
pubmed-author:SleemanMark WMW,
pubmed-author:TovarSulayS,
pubmed-author:TschöpMatthias HMH,
pubmed-author:VázquezMaría JMJ,
pubmed-author:VarelaLuisL,
pubmed-author:Vidal-PuigAntonioA
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-99
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18460330-Animals,
pubmed-meshheading:18460330-Antigens, CD95,
pubmed-meshheading:18460330-Blotting, Western,
pubmed-meshheading:18460330-Carnitine O-Palmitoyltransferase,
pubmed-meshheading:18460330-Fasting,
pubmed-meshheading:18460330-Fatty Acid Synthetase Complex,
pubmed-meshheading:18460330-Fatty Acids,
pubmed-meshheading:18460330-Feeding Behavior,
pubmed-meshheading:18460330-Ghrelin,
pubmed-meshheading:18460330-Hypothalamus,
pubmed-meshheading:18460330-In Situ Hybridization,
pubmed-meshheading:18460330-Leptin,
pubmed-meshheading:18460330-Male,
pubmed-meshheading:18460330-Malonyl Coenzyme A,
pubmed-meshheading:18460330-Mice,
pubmed-meshheading:18460330-Mice, Inbred C57BL,
pubmed-meshheading:18460330-Mice, Knockout,
pubmed-meshheading:18460330-Mice, Obese,
pubmed-meshheading:18460330-Phosphorylation,
pubmed-meshheading:18460330-Protein Kinases,
pubmed-meshheading:18460330-Rats,
pubmed-meshheading:18460330-Rats, Sprague-Dawley
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pubmed:year |
2008
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pubmed:articleTitle |
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
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pubmed:affiliation |
Department of Physiology, School of Medicine, University of Santiago de Compostela, S. Francisco s/n, 15782 Santiago de Compostela (A Coruña), Spain. miguellp@usc.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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