Integrins link the extracellular matrix to the cytoskeleton via a complex of proteins: the integrin-cytoskeleton link. A recent study in Drosophila has uncovered a new component of the link, Wech, and shown that it is essential for integrin-mediated adhesion.
Gurdon Institute of Cancer and Developmental Biology, and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.