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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-7
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pubmed:abstractText |
The specific binding of HeLa cell factors to DNA sequences at the Epstein-Barr virus (EBV) latent origin of DNA replication was detected by gel shift experiments and DNase I footprinting analysis. These cellular proteins protected at least five discrete regions of the DNA replication origin. The viral protein required for EBV plasmid replication, EBV nuclear antigen 1 (EBNA-1), binds to specific sequences within the origin region. The HeLa cell proteins competed with EBNA-1 for binding to EBV origin DNA in vitro, leading to the possibility that these cellular proteins regulate EBV DNA replication by displacing EBNA-1 at the origin sites.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-178878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2412231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2542577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2542609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2545906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2547525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2983224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-2996781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-3016506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-3018528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-3025615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-3033303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-4362625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-6087149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-6087322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-6092676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1845905-6328526
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
514-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1845905-Antigens, Viral,
pubmed-meshheading:1845905-Base Sequence,
pubmed-meshheading:1845905-Cell Nucleus,
pubmed-meshheading:1845905-DNA, Viral,
pubmed-meshheading:1845905-DNA Replication,
pubmed-meshheading:1845905-Deoxyribonuclease I,
pubmed-meshheading:1845905-Epstein-Barr Virus Nuclear Antigens,
pubmed-meshheading:1845905-HeLa Cells,
pubmed-meshheading:1845905-Herpesvirus 4, Human,
pubmed-meshheading:1845905-Humans,
pubmed-meshheading:1845905-Molecular Sequence Data,
pubmed-meshheading:1845905-Nuclear Proteins,
pubmed-meshheading:1845905-Nucleotide Mapping,
pubmed-meshheading:1845905-Oligonucleotide Probes,
pubmed-meshheading:1845905-Plasmids,
pubmed-meshheading:1845905-Protein Binding
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pubmed:year |
1991
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pubmed:articleTitle |
Identification of cellular factors that bind specifically to the Epstein-Barr virus origin of DNA replication.
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pubmed:affiliation |
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544-1014.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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