Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2008-6-16
pubmed:abstractText
When endoplasmic reticulum (ER) homeostasis is perturbed, an adaptive mechanism is triggered and named the unfolded protein response (UPR). Thus far, three known UPR signaling branches (IRE-1, PERK, and ATF-6) mediate the reestablishment of ER functions but can also lead to apoptosis if ER stress is not alleviated. However, the understanding of the molecular mechanisms integrating the UPR to other ER functions, such as membrane traffic or endomembrane signaling, remains incomplete. We consequently sought to identify new regulators of UPR-dependent transcriptional mechanisms and focused on a family of proteins known to mediate, among other, ER-related functions: the small GTP-binding proteins of the RAS superfamily. To this end, we used transgenic UPR reporter Caenorhabditis elegans strains as a model to specifically silence small-GTPase expression. We show that the Rho subfamily member CRP-1 is an essential component of UPR-induced transcriptional events through its physical and genetic interactions with the AAA+ ATPase CDC-48. In addition, we describe a novel signaling module involving CRP-1 and CDC-48 which may directly link the UPR to DNA remodeling and transcription control.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-10597630, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-10972878, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-11087817, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-11146546, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-11179901, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-11780124, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-11907268, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-11931639, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12186849, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12475790, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12519996, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12529635, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12679813, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12892791, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-12937274, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-14711675, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15037256, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15168510, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15238254, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15260967, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15261668, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15338614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15659649, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15814614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-1582407, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15907843, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-15952902, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16042567, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16184190, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16188923, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16199871, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16488589, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16793541, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16815977, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-16914519, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17098935, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17486083, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17525332, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17562790, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17565364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17584070, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17850180, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-17953399, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-18006802, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-4366476, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-6176282, http://linkedlifedata.com/resource/pubmed/commentcorrection/18458060-8249487
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases, http://linkedlifedata.com/resource/pubmed/chemical/Azetidinecarboxylic Acid, http://linkedlifedata.com/resource/pubmed/chemical/CDC48 protein, http://linkedlifedata.com/resource/pubmed/chemical/CRP-1 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Dithiothreitol, http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Multiprotein Complexes, http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin, http://linkedlifedata.com/resource/pubmed/chemical/Tunicamycin, http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1098-5549
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4261-74
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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