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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-3-18
|
| pubmed:abstractText |
In the five Nordic countries, 808 children 1 to 15 years of age (428 boys, 380 girls) were diagnosed with non-B acute lymphoblastic leukemia (ALL) from July 1981 through June 1986. Complete remission was achieved in 770 children (95%). Central nervous system (CNS) involvement at diagnosis was noticed in 34 children, of whom 26 achieved remission. Of these 26 patients 11 subsequently relapsed, 5 in the central nervous system. An interim analysis in January 1990 (observation time 3 1/2 to 8 1/2 years) revealed that isolated CNS relapse had occurred in 70 children (9.0%). Of these 70 patients, 12 out of 142 children (8.5%) had initially received irradiation and 58 out of 628 children (9.2%) only chemotherapy as CNS-prophylaxis. There was a significant higher risk for boys (12%) than for girls (6%) to relapse in the CNS compartment. Unfavorable prognostic factors for survival after isolated CNS relapse were short duration of first remission and male sex. In high-risk patients after an isolated CNS relapse, there was no difference in prognosis related to treatment with or without irradiation as initial CNS prophylaxis.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0888-0018
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
291-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1845651-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1845651-Brain Neoplasms,
pubmed-meshheading:1845651-Combined Modality Therapy,
pubmed-meshheading:1845651-Female,
pubmed-meshheading:1845651-Humans,
pubmed-meshheading:1845651-Iceland,
pubmed-meshheading:1845651-Incidence,
pubmed-meshheading:1845651-Male,
pubmed-meshheading:1845651-Pilot Projects,
pubmed-meshheading:1845651-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:1845651-Prognosis,
pubmed-meshheading:1845651-Recurrence,
pubmed-meshheading:1845651-Remission Induction,
pubmed-meshheading:1845651-Retrospective Studies,
pubmed-meshheading:1845651-Risk Factors,
pubmed-meshheading:1845651-Scandinavia,
pubmed-meshheading:1845651-Sex Characteristics,
pubmed-meshheading:1845651-Survival Rate
|
| pubmed:articleTitle |
Central nervous system disease in childhood acute lymphoblastic leukemia: prognostic factors and results of treatment.
|
| pubmed:affiliation |
Department of Pediatrics, University Hospital, Uppsala, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|