Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-5-27
pubmed:abstractText
The mammalian cerebellum is composed of a highly reproducible array of transverse zones, each of which is subdivided into parasagittal stripes. By using a combination of Purkinje cell antigenic markers and afferent tracing, four transverse zones have been identified: the anterior zone (AZ: approximately lobules I-V), the central zone (CZ: approximately lobules VI-VII), the posterior zone (PZ: approximately lobules VIII-dorsal IX) and the nodular zone (NZ: approximately ventral lobule IX+lobule X). Neurofilament-associated antigen (NAA) is an epitope recognized by a monoclonal antibody, which is expressed strongly in association with neurofilaments. During perinatal cerebellar development, anti-NAA immunocytochemistry reveals novel features of cerebellar organization. In particular, the CZ is reproducibly subdivided into anterior and posterior components. Between embryonic day 17 and postnatal day 7 NAA immunoreactivity is expressed selectively by a parallel fiber bundle that is restricted to lobule VII, thereby distinguishing the CZ anterior (lobules VIa, b) from the CZ posterior (lobule VII). The novel restriction boundary at lobule VII/VIII, which is also reflected in the morphology of the external granular layer and aligns with a gap in the developing Purkinje cell layer, precedes the morphological appearance of the posterior superior fissure between lobules VIb and VII. In addition, afferent axons to the CZ terminate in an array of parasagittal stripes that is probably a specific climbing fiber projection. Thus, the transverse zone architecture of the mouse cerebellum is more complex than had previously been appreciated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Protein, Vitamin..., http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neurofilament Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides, http://linkedlifedata.com/resource/pubmed/chemical/PAX6 protein, http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/calbindin, http://linkedlifedata.com/resource/pubmed/chemical/neurofilament protein H
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1190-201
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed-meshheading:18455884-Animals, pubmed-meshheading:18455884-Animals, Newborn, pubmed-meshheading:18455884-Body Patterning, pubmed-meshheading:18455884-Calcium-Binding Protein, Vitamin D-Dependent, pubmed-meshheading:18455884-Cerebellum, pubmed-meshheading:18455884-Embryo, Mammalian, pubmed-meshheading:18455884-Epitopes, pubmed-meshheading:18455884-Eye Proteins, pubmed-meshheading:18455884-Gene Expression Regulation, Developmental, pubmed-meshheading:18455884-Homeodomain Proteins, pubmed-meshheading:18455884-Luminescent Proteins, pubmed-meshheading:18455884-Mice, pubmed-meshheading:18455884-Mice, Inbred C57BL, pubmed-meshheading:18455884-Mice, Transgenic, pubmed-meshheading:18455884-Nerve Tissue Proteins, pubmed-meshheading:18455884-Neurofilament Proteins, pubmed-meshheading:18455884-Neuropeptides, pubmed-meshheading:18455884-Paired Box Transcription Factors, pubmed-meshheading:18455884-Purkinje Cells, pubmed-meshheading:18455884-Repressor Proteins
pubmed:year
2008
pubmed:articleTitle
A novel transverse expression domain in the mouse cerebellum revealed by a neurofilament-associated antigen.
pubmed:affiliation
Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't