Linked Life Data

18455800

Source:http://linkedlifedata.com/resource/pubmed/id/18455800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-5-20
pubmed:databankReference
pubmed:abstractText
Pathogen-driven selection is believed to be important in the evolution and maintenance of the polymorphism of the major histocompatibility complex (MHC) genes but have been tested for very few vertebrates. In this study, we first investigate by SSCP (single strand conformational polymorphism) the diversity found at the MHC class IIbeta gene in a population of brook charr (Salvelinus fontinalis) from the Rupert River (Québec, Canada). Secondly, to explore the survival performances conferred by specific alleles and genotypes, individuals from 23 half- and full-sibling families were infected with Aeromonas salmonicida, the causative agent of furonculosis. From the initial brook charr population, a total of six MHC class IIbeta alleles were identified; four complete and two partial coding sequences that include the complete polymorphic beta1 domain. One allele, Safo-DAB*0101, was significantly associated with resistance against A. salmonicida. In addition to homozygotes for this allele, its resistance effect was also detected in heterozygotes for two specific genotypes. Other allelic combinations, namely heterozygous genotypes Safo-DAB*0201/*0301 and Safo-DAB*0301/*0401 were significantly associated with increased susceptibility to furonculosis. Given that its frequency was relatively low (0.0873), the negative frequency-dependent selection hypothesis could explain the advantage associated with the allele Safo-DAB*0101 over the other alleles and highlight the importance of this mechanism to sustain variation at the MHC in brook charr.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0161-5890
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3107-16
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Identification of MHC class IIbeta resistance/susceptibility alleles to Aeromonas salmonicida in brook charr (Salvelinus fontinalis).
pubmed:affiliation
Département de Microbiologie et Immunologie, Université de Montréal, Montréal, Québec H3C 3J7, Canada. sébastien.croisetiere@umontreal.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't