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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-6-30
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pubmed:abstractText |
The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin-2-stimulated T-cell division. Rapamycin has also been suggested to possess strong anti-angiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF). Angiogenesis and VEGF are thought to play a crucial role in fracture healing and as osteoporotic and traumatic fractures are common complications in immunosuppressed, organ transplantation patients, we conducted this study to analyze the effect of rapamycin treatment on bone repair.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-10371499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-10495271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-11057898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-11821896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-11889427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-12682881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-12940519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-1471500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-15692359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-15963777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-16234976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-16376352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-16827677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-16894343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-17161437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-17384960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-17476476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-17516572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-3455637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-3981300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-7543725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-7976298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-8878772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-9240731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-9552353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18454167-9872925
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1188
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pubmed:author |
pubmed-author:CulemannUU,
pubmed-author:GarciaPP,
pubmed-author:HistingTT,
pubmed-author:HolsteinJ HJH,
pubmed-author:KleinMM,
pubmed-author:LaschkeM WMW,
pubmed-author:MeierCC,
pubmed-author:MengerM DMD,
pubmed-author:PizanisAA,
pubmed-author:PohlemannTT,
pubmed-author:ScheuerCC,
pubmed-author:SchorrHH
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pubmed:issnType |
Print
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1055-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18454167-Angiogenesis Inhibitors,
pubmed-meshheading:18454167-Animals,
pubmed-meshheading:18454167-Biomechanics,
pubmed-meshheading:18454167-Blotting, Western,
pubmed-meshheading:18454167-Bony Callus,
pubmed-meshheading:18454167-Cell Proliferation,
pubmed-meshheading:18454167-Chondrocytes,
pubmed-meshheading:18454167-Disease Models, Animal,
pubmed-meshheading:18454167-Endothelial Cells,
pubmed-meshheading:18454167-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18454167-Femoral Fractures,
pubmed-meshheading:18454167-Fracture Healing,
pubmed-meshheading:18454167-Immunohistochemistry,
pubmed-meshheading:18454167-Immunosuppressive Agents,
pubmed-meshheading:18454167-Mice,
pubmed-meshheading:18454167-Neovascularization, Physiologic,
pubmed-meshheading:18454167-Osteoblasts,
pubmed-meshheading:18454167-Osteogenesis,
pubmed-meshheading:18454167-Sirolimus,
pubmed-meshheading:18454167-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Rapamycin affects early fracture healing in mice.
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pubmed:affiliation |
Department of Trauma, Hand and Reconstructive Surgery, Homburg/Saar, Germany. chjhol@uniklinikum-saarland.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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