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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-7-2
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pubmed:abstractText |
Collagen, as a component of the extracellular matrix, has been linked to atherosclerotic plaque formation and stability. Activation of LOX-1, a lectin-like oxidized low-density lipoprotein (LDL) receptor-1, exerts a significant role in collagen formation. We examine the hypothesis that LOX-1 deletion may inhibit collagen accumulation in atherosclerotic arteries in LDL receptor (LDLR) knockout (KO) mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Olr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Osteopontin,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class E
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-93
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18453637-Animals,
pubmed-meshheading:18453637-Aorta,
pubmed-meshheading:18453637-Atherosclerosis,
pubmed-meshheading:18453637-Cholesterol, Dietary,
pubmed-meshheading:18453637-Collagen,
pubmed-meshheading:18453637-Extracellular Matrix,
pubmed-meshheading:18453637-Fibronectins,
pubmed-meshheading:18453637-Male,
pubmed-meshheading:18453637-Matrix Metalloproteinases,
pubmed-meshheading:18453637-Mice,
pubmed-meshheading:18453637-Mice, Inbred C57BL,
pubmed-meshheading:18453637-Mice, Knockout,
pubmed-meshheading:18453637-Nitric Oxide Synthase Type III,
pubmed-meshheading:18453637-Osteopontin,
pubmed-meshheading:18453637-Oxidative Stress,
pubmed-meshheading:18453637-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18453637-Receptors, LDL,
pubmed-meshheading:18453637-Scavenger Receptors, Class E
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pubmed:year |
2008
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pubmed:articleTitle |
LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet.
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pubmed:affiliation |
Department of Internal Medicine, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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