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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-7-29
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pubmed:abstractText |
Serum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte-secreted acute-phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin (IL)-1beta was determined in 3T3-L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL-1beta in a time-dependent fashion with maximal induction after 24 h. Furthermore, IL-1beta significantly induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1beta-induced SAA3 expression was mediated by nuclear factor-kappaB and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-4644
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2241-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18452164-3T3-L1 Cells,
pubmed-meshheading:18452164-Adipocytes,
pubmed-meshheading:18452164-Animals,
pubmed-meshheading:18452164-Dose-Response Relationship, Drug,
pubmed-meshheading:18452164-Gene Expression Regulation,
pubmed-meshheading:18452164-Interleukin-1beta,
pubmed-meshheading:18452164-Janus Kinase 2,
pubmed-meshheading:18452164-Mice,
pubmed-meshheading:18452164-NF-kappa B,
pubmed-meshheading:18452164-RNA, Messenger,
pubmed-meshheading:18452164-Serum Amyloid A Protein,
pubmed-meshheading:18452164-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes.
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pubmed:affiliation |
Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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